Search results for " folic"
showing 10 items of 14 documents
Comparison Study of Two Differently Clicked 18F-Folates—Lipophilicity Plays a Key Role
2018
Within the last decade, several folate-based radiopharmaceuticals for Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET) have been evaluated; however, there is still a lack of suitable 18F-folates for clinical PET imaging. Herein, we report the synthesis and evaluation of two novel 18F-folates employing strain-promoted and copper-catalyzed click chemistry. Furthermore, the influence of both click-methods on lipophilicity and pharmacokinetics of the 18F-folates was investigated. 18F-Ala-folate and 18F-DBCO-folate were both stable in human serum albumin. In vitro studies proved their high affinity to the folate receptor (FR). The lipophilic character of …
Comparative validity of the ASSO - Food Frequency Questionnaire for the web-based assessment of food and nutrients intake in adolescents
2015
Background : A new web-based food frequency questionnaire (the ASSO–FFQ) was developed within the ASSO Project funded by the Italian Ministry of Health. Objective : The aim of the present study is to assess the validity of the ASSO–FFQ at food groups, energy, and nutrients level. Design and subjects : The validation study compared the ASSO–FFQ against a weighted food record (WFR) measuring foods, beverages and supplements intake, compiled during the week following the ASSO–FFQ administration. Ninety-two subjects aged 14–17, recruited from secondary schools in Palermo (Italy), completed the ASSO–FFQ and WFR. The intake of 24 food groups, energy, and 52 nutrients were taken as main outcomes. …
Effect of actively targeted copolymer coating on solid tumors eradication by gold nanorods-induced hyperthermia.
2020
Efforts in the field of anticancer therapy are increasingly focusing on the development of localized and selective treatments. Photothermal therapy (PTT) can lead to a spatially confined death of cancer cells, exploiting an increasing in temperature generated after UV-NIR irradiation of peculiar materials. Herein, a new actively targeted gold-based drug delivery system, named PHEA-LA-Fol-AuNRs/Iri, was explored for hyperthermia and chemotherapy colon cancer treatment. Gold nanorods were stabilized using a folate-derivative of α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA-LA-PEG-FA) as coating agent and then loaded with the antineoplastic drug irinotecan (Iri). The efficacy of empty and i…
Are the Recommended Dietary Allowances for Vitamins Appropriate for Elderly People?
2015
Background: An adequate vitamin intake is essential for a good nutritional status, especially in older women, who are more sensitive to nutritional deficiencies. The American, European and Italian Recommended Dietary Allowances (RDAs) derive mainly from studies on adults, and it is not clear whether they also apply to elderly people. Comparing the RDAs with the actual vitamin intake of a group of healthy older women could help to clarify the real needs of elderly people. Objective: Our aim was to compare the American, European, and Italian RDAs with the actual vitamin intake of a group of healthy older women. Design: This was a cross-sectional study. Participants: The study included 286 hea…
Folate deficiency as predisposing factor for childhood leukaemia: a review of the literature
2017
© The Author(s). 2017. Background: Folic acid and its derivates, known as folates, are chemoprotective micronutrients of great interest because of their essential role in the maintenance of health and genomic integrity. The supplementation of folic acid during pregnancy has long been known to reduce the risk of neural tube defects (NTDs) in the foetus. Folate metabolism can be altered by many factors, including adequate intake through diet. Folate deficiency can compromise the synthesis, repair and methylation of DNA, with deleterious consequences on genomic stability and gene expression. These processes are known to be altered in chronic diseases, including cancer and cardiovascular diseas…
Activacion folicular mediante fragmentación de la corteza ovárica como tratamiento de la esterilidad asociada a baja reserva ovárica y la insuficienc…
2017
La vía de Salvador / Warts / Hippo está implicada en la coordinación de la proliferación y muerte celular, esencial para el mantenimiento del tamaño de los órganos y la homeostasis de los tejidos durante la vida postnatal. Recientemente se ha descrito en modelos in vitro y en modelos animales cómo la disrupción de la vía Hippo promueve la activación y el crecimiento de folículos primordiales. Igualmente existe una pequeña serie en humanos en la que, tras aplicar la disrupción de dicha vía mediante un triple abordaje (fragmentación tisular, incubación con inhibidores de PTEN y activadores de PI3K), se han descrito dos casos de recién nacidos vivos en pacientes con un fallo ovárico prematuro.…
Modulación de expresión génica y proteica de los receptores de FSH y de andrógenos en las células foliculares en pacientes con baja respuesta ovárica…
2014
Las mujeres infértiles susceptibles de presentar una inadecuada respuesta ovárica a los protocolos de estimulación ovárica controlada representan uno de los principales desafíos en la práctica clínica diaria. Fundamentalmente se debe a la compleja identificación a priori de estas pacientes, en base a unos parámetros clínicos íntimamente relacionados con la reserva ovárica disminuida. Asimismo, a pesar de existir numerosas pautas terapéuticas consideradas en el manejo clínico de la paciente con baja respuesta ovárica, no se ha consensuado aquella de mayor efectividad sobre el rendimiento ovárico. Las terapias adyuvantes a los protocolos de estimulación ovárica controlada persiguen mejorar la…
Haematological deficiencies in patients with recurrent aphthosis
2010
Background Recurrent aphthosis is a common oral ulcerative condition consisting also of a subset of similar ulcers, properly named 'aphthous-like' ulcers (ALU), linked to systemic diseases and among these, to iron, folic acid and vitamin B(12) deficiencies. Objectives The main objectives of this study were: (i) to evaluate the association between recurrent aphthosis and the most common predisposing factors; (ii) to assess the frequency of ALU in recurrent aphthosis; (iii) to verify the efficacy of a replacement therapy in all ALU patients. Methods Thirty-two adults with recurrent aphthosis and 29 otherwise healthy controls were consecutively recruited, interviewed and subjected to haematolo…
Efecto biológico de la FSH recombinante de codorniz común en la inducción del ciclo ovárico en aves
2018
La reproducción ex situ es una de las medidas reconocidas por la comunidad científica y conservacionista para la conservación de especies amenazadas y su reintroducción en el medio natural. Sin embargo, la reproducción en cautividad de especies de aves amenazadas fracasa con frecuencia debido a la ausencia de estímulos ambientales asociada a la vida en cautividad. Esta circunstancia impide el desarrollo de los ciclos reproductivos fisiológicos en condiciones naturales y, por tanto, la obtención de progenie a partir de individuos valiosos desde el punto de vista de la diversidad genética y ecológica. De modo general y, en resumen, los estímulos ambientales, a través de un conjunto de eventos…
Synthesis and Characterisation of Functionalized borosilicate nanoparticles for boron neutron capture therapy applications
2012
Boron Neutron Capture Therapy (BNCT) is a promising therapy for the cure of diffuse tumors. The successful clinical application of BNCT requires finding new boron-based compounds suitable for an efficient 10B delivery to the cancerous tissues. The purpose of this work is to synthesize borosilicate nanoparticles by a sol–gel recipe, and to functionalize them with folic acid in order to promote their capture by the tumor cells. Whereas sol–gel is a promising technique for the synthesis of nanoparticles, in case of borosilicate systems this approach is affected by significant boron loss during preparation. Here we show that functionalization of borosilicate nanoparticles with folic acid can re…